Clean Up Computer

How do I clean up my computer? It is running slow and I have to X out pop-up before even logging into email?

I have pop-up blocker that shows it is enabled, but I still get pop-ups every time I log. Also, my home page is set to Yahoo but it has been resetting itself to a "messenger site." I have to reset each time back to yahoo on a daily basis. What is this and what do I do?

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