Clean Up Computer

How to repair windows with out reformating?

a work computer got infected with advance xp defender, later on the computer was infected with spyguard, password proctect and advance xp fix. by that time the computer was unusable. i did a little search and malware bytes antimalware was the way to go. the virus got removed but now the computer wont start. as soon as windows explorer loads. it stops in the blue screen and halts in error 0x50. i search around and its caused by bad drivers loaded by the virus. i tried to erase those drivers in safe mode but they are locked even tried file assasin but still wont load.
i need to fix this asap a lot of accounting software and clients information in that computer.
the computer only loads in safe mode with command prompt
but if i load explorer it crashes
and reformating its not an option at this moment
can i repair windows with out reformating?
Please help
sorry about the long question but tried to be as specific as i can.

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