Clean Up Computer

Need spyware/virus help with a computer!! How to clean registry??

My friends computer has become infected with spyware or a virus. He is running Windows XP on a Compaq. Theres a little dialog box popping up constantly that says theres a virus on the computer. When you click on the box it redirects you to a spyware remover page. Obviously its an attempt to sell this product. How can I remove this and stop all these pop ups? I was thinking about manually cleaning the registry. How would I go about that? And what about those programs in the Add/Remove programs in control panel that just wont go away? I need to get this junk off his computer. What do I do? Without spending money that is.

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