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Please help me figure out my frustrating Windows XP issue….?

I’v had Win XP-Home edition on my PC for a long time without problems but I need help figuring this issue out :
There are 5 different logon user-accts within my household and as of this morning, 2 of them will not keep the personal settings. Both still have their desktop shortcuts but the background display & screensaver settings are gone and when I reset/apply them….. no changes occur. Their start-up button is cleared out as well. I tried to right-click the programs to pin them back onto the menu but it’s ignored. Also, when I double-click Internet Explorer to go online; it opens as if they are logging on for the first time asking for IE settings, etc…..it doesn’t go to their previously set homepages. Only from those 2 accounts though….the other 3 are okay. (I can still change the display, logon to IE and the homepages are still intact.) I have run every anti-virus; registry cleaner; ad-ware/mal-ware/spyware that I have. They detect nothing! Any ideas for me?Thanks!
Well, after all day of trying to find a solution; it seems as though I will have to delete & reset those user accounts. I have already backed-up their files and such to an external HD. Another question…is there a way to save their IE favorites so that they don’t have to "start from scratch" after logging onto the internet from the new XP accts?
Thanks everyone for the help!

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