I use:
Ad Adware SE Personal
avast!
Spybot Search and Destroy
SUPERAntiSpyware
Spyware Blaster

And to clean my registries:
CCLeaner
Abexo

What do you use and what do you think are the best?

In the past I have tried AntiVir, MacAffe and Norton and did not like too much also AVG which is crap