registry cleaners yes or no?

i dont know what to do at the moment i only use ccleaner. I know if i run reg cure netcom3 or any other it will find errors but doing this could destroy my registry. So i was thinking do i just use the free ones and if so witch one do i use. easy cleaner . Eusing Free Registry Cleaner . or do you recommend one that you know one that you 100% trust free or purchase can you help thankyou for all honest repilys on this subject

The programs I have installed now are

Uniblue spyware
Uniblue Speedup my PC
Uniblue Registry cleaner
Spybot
Windows live onecare
registry clear

I was thinking of installing Netcom3 but???