Registry Cleaners??

Do they really make much of a difference performance wise??? Should i get one like ccleaner or tune-up utilities??
I want to know because i am deciding between norton 360 2.0 and norton internet security 2008 and the only difference i care about is that the new 360 also includes a reg cleaner.

Help appreciated!!

I have Norton Internet Security 2008 on my pc. Do I need to clean my registry as I had recently some crashes. I run uniblue registry cleaner and have found hundred of suspicious programs on my pc. When I wanted to remove them i received an alert that I need to purchase this program. Do I have an integrated tool in NIS 2008 to clean the registry? Thank you in advance.