I’m building a computer. I’m spending a lot of money on it. I want to know ALL protection needed to keep my computer clean and healthy.

What is the best program for the following? (Preferably NOT free)

Anti-Virus
Anti-Spyware/Malware/Adware
Disk Defragmenter
Registry Cleaner
Disk Cleanup

And if I missed any other cleaning/health program, please specify!
And I don’t necessarily mean one program for all.