Can I have 2 registry cleaners on my computer?

I've read quite a few articles on registry cleaners and some say they are safe but others say the opposite.
So are registry cleaners really safe?
Thanks guys.
Y!Answers always gives me answers to computer stuffs =3

Anyone give me some suggestions on registry cleaners that do their job time after time and that may work better than others?

Thank you.

Are all registry cleaners avalable in download only options? I'd like to get the package/cd instead.

Thanks for your help.

There are so many registry cleaners nowadays. Maybe somebody knows what is the most effective.